KNEE3D
3D bone mapping
We can provide accurate, robust and reliable 3D surface-based bone parameter mapping from CT imaging using our expert 3D segmentations as the framework. This includes measures such as cortical thicknes, cortical density, subcortical trabecular attenuation and, if a QCT calibration phantom is included in the data, bone mineral density.
The 3D triangulated mesh is the framework for measuring these parameters around cortical bone across an entire object surface using a validated alogrithm.
Here we can see cortical thickness mapped around the knee joint from weight bearing CT in a "normal" individual with no apparent structural features of osteoarthritis, first as a colour map on the mesh, then as a colour wash across surfaces.
The colour scale for cortical bone thickness ranges from red (0 mm) to blue (23 mm)
COMPARING 3D BONE MAPPING DATA
Here are some practical examples of cortical bone density from weight bearing CT comparing a "normal" individual with no apparent structural features of knee osteoarthritis (OA) compared to someone with features of medial tibiofemoral OA.
The colour scale for cortical bone density ranges from red (700 Hounsfield units) to blue (2100 Hounsfield units).
Note how the individual with OA shows greater cortical density values (more blue in the wash) around the medial margin of the medial tibiofemoral compartment (right of the image), which could be an effect of increased bone stress/loading/response in the setting of the adjacent osteoarthritic phenomena.
See our 3D registrations for how these maps can be transferred to a "canonical" surface that allows visualisation of aggregate data from an entire study group, different individuals to be compared with each other and the same individual to be compared across multiple timepoints...
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